Graduate Education: M.D. Degree (1981), University of Zurich, Switzerland.

Postgraduate Education: Postgraduate Course in Experimental Medicine and Biology. University of Zurich, Switzerland.

Positions as Geneticist: University of Zurich, Switzerland (2 years); The Jackson Laboratory, Bar Harbor, Maine (7 years); National Institutes of Health, Phoenix, Arizona (15 years).

Molecular Genetics: Chromosomal mapping and analyses of DNA markers (PCR, SSCP, RFLP, AFLP); determination of exon-intron structure of genes, and identification of new polymorphic markers; scanning of genomic DNA for mutations; development of DNA tests; large scale DNA marker testing; DNA restriction mapping and sequencing.

Laboratory Management: Setting-up a molecular genetics lab; training of staff in molecular genetics techniques; supervising DNA marker testing and mutation screening.

• Staeheli P, Prochazka M, Steigmeier PA, Haller O. Genetic control of interferon action: Mouse strain distribution and inheritance of an induced protein with guanylate-binding properties. Virology 1984; 137:135-142.

• Prochazka M, Staeheli P, Holmes RS, Haller O. Interferon-induced guanylate-binding proteins: Mapping of the murine Gbp-1 locus to chromosome 3. Virology 1985; 145:273-279.

• Frater-Schroder M, Prochazka M, Haller O, Arwert F, Porch HJ, Skow LC, Lundin L-G, Hilkens J, Hilgers J. Localization of the gene for the vitamin B12 binding protein, transcobalamin II, near the centromere on mouse chromosome 11, linked to the hemoglobin alpha-chain locus. Biochemical Genetics 1985; 23:139-153.

• Leiter EH, Prochazka M, Coleman DL, Serreze DV, Shultz LD. Genetic factors predisposing to diabetes susceptibility in mice. In: The Immunology of Diabetes. Jaworski MA, Mollnar GD, Rajotte RV, Singh B, eds. Elsevier Int. Cong. Series, Amsterdam 1986; Series 717: 29-36.

• Prochazka M, Leiter EH, Serreze DV, Coleman DL. Identification of three recessive loci required for insulin-dependent diabetes in non-obese diabetic (NOD) mice. Science 1987; 237: 286-289.

• Novak EK, Sweet HO, Prochazka M, Parentis M, Soble R, Reddington M, Cario A, Swank RT. Cocoa: A new mouse model for platelet storage pool deficiency. British Journal of Haematology 1988; 69: 371-378.

• Prochazka M, Kozak UC, Kozak LP. A glycerol-3-phosphate dehydrogenase null mutant in BALB/cHeA mice. Journal of Biological Chemistry 1989; 264: 4679-4683.

• Shiffer SP, Prochazka M, Jezyk PF, Roderick TH, Yudkoff M, Patterson DF. Organic aciduria and butyryl CoA dehydrogenase deficiency in BALB/cByJ mice. Biochemical Genetics 1989; 27: 47-58.

• Prochazka M, Gaskins HR, Leiter EH, Koch-Nolte F, Haag F, Thiele H-G. Chromosomal localization, DNA polymorphism, and expression of Rt-6, the mouse homologue of rat T lymphocyte differentiation marker RT6. Immunogenetics 1991; 33: 152-156.

• Prochazka M, Gaskins HR, Shultz LD, Leiter EH. The nonobese diabetic scid mouse: Model for spontaneous thymomagenesis associated with immunodeficiency. Proceedings of the National Academy of Sciences USA 1992; 89: 3290-3294.

• Choi MG, Prochazka M, Thuillez P, Lillioja S. A new TaqI allele detected by the CRI-R227 (D4S101) probe in Pima Indians. Nucleic Acids Research 1992; 20: 1157.

• Prochazka M, Lillioja S, Tait JF, Knowler WC, Mott DM, Spraul M, Bennett PH, Bogardus C. Linkage of chromosomal markers on 4q with a putative gene determining maximal insulin action in Pima Indians. Diabetes 1993; 42: 514-519.

• Mochizuki H, Prochazka M. Dinucleotide repeat polymorphism at the PPP1CA locus on 11q13. Human Molecular Genetics 1994; 3:2265.

• Baier LJ, Sacchettini JC, Knowler WC, Eads J, Paolisso G, Tataranni PA, Mochizuki H, Bennett PH, Bogardus C, Prochazka M. An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance. Journal of Clinical Investigation 1995; 95:1281-1287.

• Prochazka M, Mochizuki H, Baier LJ, Cohen PTW, Bogardus C. Molecular and linkage analysis of type-1 protein phosphatase catalytic beta-subunit gene: lack of evidence of its major role in insulin resistance in Pima Indians. Diabetologia 1995; 38:461-466.

• Ardehali H, Tiller GE, Printz RL, Mochizuki H, Prochazka M, Granner DK. A novel (TA)_n polymorphism in the hexokinase II gene: application to noninsulin-dependent diabetes mellitus in the Pima Indians. Human Genetics 1996; 97:482-485.

• Prochazka M. Microsatellite hybrid capture technique for simultaneous isolation of various STR markers. Genome Research 1996; 6:646-649.

• Rowles JC, Scherer SW, Xi T, Majer M, Nickle DC, Rommens JM, Popov KM, Harris RA, Riebow NL, Xia J, Tsui L-C, Bogardus C, Prochazka M. Cloning and characterization of PDK4 on 7q21.3 encoding a fourth pyruvate dehydrogenase kinase isoenzyme in human. Journal of Biological Chemistry 1996; 271:22376-22382.

• Wolford JK, Prochazka M. Structure and expression of the human MTG8/ETO gene. Gene, 1998; 212:103-109.

• Mochizuki H, Scherer SW, Xi T, Nickle DC, Majer M, Huizenga JJ, Tsui L-C, Prochazka M. Human PON2 gene at 7q21.3: cloning, multiple mRNA forms, and missense polymorphisms in the coding sequence. Gene, 1998; 213:149-157.

• Wolford JK, Bogardus C, Prochazka M. Polymorphism in the 3’ untranslated region of MTG8 is associated with obesity in Pima Indian Males. Biochemical and Biophysical Research Communications 1998; 246:624-626.

• Xia J, Scherer SW, Cohen PTW, Majer M, Xi T, Norman RA, Knowler WC, Bogardus C, Prochazka M. A common variant in PPP1R3 associated with insulin resistance and type 2 diabetes. Diabetes 1998; 47:1519-1524.

• Wolford JK, Bogardus C, Prochazka M. Genome-wide scan for CAG/CTG repeat expansions in Pimas with early onset of type 2 diabetes mellitus. Molecular Genetics and Metabolism 1999; 66:62-67.

• Wolford JK, Bogardus C, Ossowski V, Prochazka M. Molecular characterization of the human PEA15 gene on 1q21-q23 and association with type 2 diabetes mellitus in Pima Indians. Gene 2000; 241:143-148.

• Wolford JK, Blunt D, Ballecer C, Prochazka M. High-throughput SNP detection by using DNA pooling and denaturing high performance liquid chromatography (DHPLC). Human Genetics 2000; 107:483-487.

• Prochazka M, Walder K, Xia J. AFLP fingerprinting of the human genome. Human Genetics 2001; 108:59-65.

• Thameem F, Wolford JK, Bogardus C, Prochazka M. Analysis of PBX1 as a candidate gene for type 2 diabetes mellitus in Pima Indians. Biochimical and Biophysical Acta 2001; 1518:215-220.

• Wolford JK, Hanson RL, Kobes S, Bogardus C, Prochazka M. Association of polymorphisms in the KCNJ9 gene with type 2 diabetes mellitus in Pima Indians. Molecular Genetics and Metabolism 2001; 73:97-103.

• Wolford JK, Thameem F, Bogardus C, Prochazka M. Molecular analysis of the insulin receptor-related receptor gene (INSRR) on 1q in Pima Indians. Molecular and Cellular Probes 2001; 15:223-227.

• Wolford JK, Hanson RL, Bogardus C, Prochazka M. Analysis of the Lamin A/C gene as a candidate for type 2 diabetes susceptibility in Pima Indians. Diabetologia 2001; 44:779-782.

• Thameem F, Wolford JK, Wang J, German MS, Bogardus C, Prochazka M. Cloning, expression and genomic structure of human LMX1A, and variant screening in Pima Indians. Gene 2002; 290:217-225.

• Prochazka M, Farook V, Ossowski V, Wolford JK, Bogardus C. Variant screening of PRKAB2, a type 2 diabetes mellitus susceptibility candidate gene on 1q in Pima Indians. Molecular and Cellular Probes 2002; 16:421-427.

• Farook V, Hansen R, Wolford JK, Bogardus C, Prochazka M. Molecular analysis of KCNJ10 on 1q as a candidate gene for type 2 diabetes mellitus in Pima Indians. Diabetes 2002; 51:3342-3346.